Mutinous, German and Spanish mercenaries, from Charles V's army led by Charles III, Duke of Bourbon, attacked Rome on May 6, 1527, sacking the city and causing immense destruction in Rome. The Duke of Bourbon, died in the initial attack but the troops continued the attack and the looting until February 1528. The attack cost the lives of 147 Swiss guards.
Pope Clement VII escaped to Castel Sant'Angelo where he was trapped for seven months, and forced to pay 400,000 ducats, cede territory, and agree to political terms. He escaped, disguised as a peddler before paying the full ransom. The event occurred during the Italian Wars as a result of a power struggle between the Pope and the Emperor; although the Emperor was not aware or sanctioned the attack on Rome. Up to 90% of the city’s art treasures were stolen or destroyed and The looting resulted in many people killed from murder, famine, and the plague, causing widespread destruction, effectively ending the High Renaissance in Rome and affecting the European power dynamics.