The Great Schism, the separation of the Eastern Orthodox Church and the Roman Catholic Church takes place when papal legate Cardinal Humbert, excommunicates the Patriarch of Constantinople, Michael Cerularius. The Patriarch and his council responded four days later by excommunicating Cardinal Humbert, formally enacting the split.
Key factors leading to the separation of the Eastern Orthodox Church and the Roman Catholic Church included disagreements over the Pope's absolute authority, and a major theological dispute over the "Filioque" clause in the Nicene Creed. The original creed stated the Holy Spirit proceeds from the Father, but the West changed it to "proceeds from the Father and the Son," which was a major concern for the East and was not agreed upon by Eastern churches.
The rift was also enhanced by growing political and cultural tensions and disagreements over practices such as married clergy (allowed in the East) versus celibacy (required in the West) and language differences (Latin in the West, Greek in the East).