Aspirin, probably the best known brand in medicine is entered in the trademark register of the Kaiserliches Patentamt (Imperial Patent Office) in Berlin on March 6, 1899, by the German company Bayer, after being first successfully synthesized.
Salicin, which is converted into salicylic acid in the body, is found in the bark of willows. Its therapeutic effect has been known since time immemorial. The progenitor of all physicians, Hippocrates of Kos, described it around 400 B.C. as a medicine against fever and pain; Teutons and Celts cooked a broth from willow bark as medicine. More
