The Thirty Years' War is ignited in Prague when a confrontation between Bohemian Protestant Nobels and representatives of the Catholic Holy Roman Emperor resulted in the representatives being thrown out a castle window (The Defenestration of Prague) on ay 23, 1618.
The event was a result of escalating religious and political tensions between Protestant and Catholic factions, triggering a rebellion and a devastating 30 year European war which ended with the treaty of Treaty of Westphalia in 1648. The war is considered one of the most destructive conflicts in history before the 20th century, causing a major change of the political map of Europe.