Columbus begins his second trip, setting sail from Cádiz, Spain, on September 24, 1493, commanding a massive fleet of 17 ships and around 1,200 men. The fleet included soldiers, priests, and colonists equipped with tools, livestock and seeds, to establish a permanent settlement.
Taking a more southerly route than his first trip, Columbus landed in the Lesser Antilles on November 3, 1493. He went on to explore and name several islands, including Dominica, Guadeloupe, Antigua, and Puerto Rico, before arriving back at Hispaniola.